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聯(lián)系人：蔣經(jīng)理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com

名稱	BCR-ABL1 Q252H/T315I /BaF3
型號	CBP73278
報價
特點	BCR-ABL1 [Q252H/T315I] /BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO；

CBP73278
I. Introduction
Cell Line Name：	BCR-ABL1 [Q252H/T315I] /BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, plays a role in regulation of cell growth through ERK5, Rac/JNK, and Stat1/3 pathways (PMID: 10373409). Fusion proteins of BCR-ABL1 resulting in constitutive kinase activity have been reported in various cancers (PMID: 18851712, PMID: 30125955) and a number of Abl1 mutations in the context of BCR-ABL1 have been demonstrated to confer drug resistance (PMID: 24456693).

III. Representative Data
1.WB of BCR-ABL1 [Q252H/T315I] /BaF3
2. Sanger of BCR-ABL1 [Q252H/T315I] /BaF3 Figure 2. BCR-ABL1 [Q252H/T315I] /BaF3 Fusion Figure 3. BCR-ABL1 [Q252H/T315I] /BaF3 Q252H Mutation Figure 4. BCR-ABL1 [Q252H/T315I] /BaF3 T315I Mutation
3. Anti-proliferation assay Figure 5 .CTG Proliferation Assay of BaF3 BCR-ABL1 T315I Q252H Cells (C1).